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Course title |
Signal Transduction in Diseases |
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Semester |
103-2 |
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Designated for |
COLLEGE OF MEDICINE GRADUATE INSTITUTE OF MICROBIOLOGY |
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Instructor |
CHING CHOW CHEN |
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Curriculum Number |
md&ph5040 |
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Curriculum Identity Number |
420 U4400 |
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Class |
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Credits |
2 |
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Full/Half
Yr. |
Half |
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Required/
Elective |
Elective |
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Time |
Friday 7,8(14:20~16:20) |
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Remarks |
The upper limit of the number of students: 120. |
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Ceiba Web Server |
http://ceiba.ntu.edu.tw/1032md_ph5040_ |
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Course introduction video |
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Table of Core Capabilities and Curriculum Planning |
Association has not been established |
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Course Syllabus
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Please respect the intellectual property rights of others and do not copy any of the course information without permission
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Course Description |
訊息傳遞與疾病 |
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Course Objective |
本課程旨在介紹細胞內分子訊息傳遞機制，闡明細胞功能的調節機制，進而認識疾病與其治療。課程內容涵蓋G-protein coupled receptors、small G proteins、signaling of receptor tyrosine kinases、regulation of transcription、signaling in immune system及腫瘤形成之相關訊息傳遞。本課程內容設計以教科書為主軸，輔以最新學術研究進展及臨床治療，希望幫助學生之研究和文獻閱讀能力。 |
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Course Requirement |
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Student Workload (expected study time outside of class per week) |
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Office Hours |
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Designated reading |
待補 |
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References |
1. Biochemistry of signal transduction and regulation / Gerhard Krauss. Weinheim :
Wiley-VCH Verlag GmbH & Co. KGaA, 2008. 4th
2. Signal transduction / Bastien D. Gomperts, Ijsbrand M. Kramer, Peter E.R.
Tatham. Amsterdam ; Boston ; London : Elsevier/Academic Press, c2009. 2nd ed
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Grading |
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Week |
Date |
Topic |
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第1週 |
02/27 |
請注意，本週不上課。 |
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第2週 |
3/06 |
Introducting:Basics of cell signaling |
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第3週 |
3/13 |
G-protein coupled signal transmission pathways |
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第4週 |
3/20 |
Intracellular messenger substances: “Second messengers” |
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第5週 |
3/27 |
Transmembrane receptors with tyrosine kinase activity |
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第6週 |
4/03 |
停課一周 |
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第7週 |
4/10 |
Signal transmission via Ras proteins |
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第8週 |
4/17 |
Protein cascades of the Mitogen-activated protein kinase pathway |
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第9週 |
4/24 |
Oncogenes and tumor suppressor genes |
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第10週 |
5/01 |
Signaling in Immune system (I) |
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第11週 |
5/08 |
Signaling to NF-κB: regulation by ubiquitination |
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第12週 |
5/15 |
Signal Transduction in Immune System (II) |
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第13週 |
5/22 |
Apoptosis |
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第14週 |
5/29 |
Epigenetic mechanisms |
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第15週 |
6/05 |
Cell adhesion and differentiation |
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第16週 |
6/12 |
Targeting transduction pathways for research and medical intervention |
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第17週 |
4/24 |
期中考成績 |